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In March 2026, ReSpindle completed the first independent blind validation of AI-powered oocyte spindle morphology analysis, conducted at Alpha IVF & Women's Specialists (Malaysia), an R&D partner since December 2024.

The AI system analyzed 186 unique polarized light images from 23 oocytes. All predictions were made before PGT-A results were disclosed.

Results: 71.2% accuracy between ReSpindle Score A/C classifications and PGT-A ground truth, with 25% of oocytes assigned Score B - a deliberate grey zone for cases with inconclusive spindle morphology.

These are early results on a limited sample. However, they represent the first independent blind validation confirming that AI analysis of oocyte spindle morphology via polarized light microscopy can correlate with PGT-A outcomes in a real clinical setting, without any contact with the embryo.

The dataset continues to grow as additional clinical partners contribute validation data.

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